During the installation of Dataflex, it asks some questions about checking the IIS installation (I can't remember the wording).

Probably 2 things that I would try in this case is:

1. Uninstall the Dataflex studio and reinstall it watching for that step in the install process that talks about IIS and being sure to run that option.

2. Install Dataflex Studio on a different computer with Windows 10 Home and see if you have success there.