I'm pretty sure it is possible now. I'm running Anniversary Edition and Process Explorer shows Chrome as being Per Monitor DPI aware, and it doesn't get scaled at all on either monitor.
I've also put the True/PM setting in the manifest file for one of our applications and this results in the DataFlex application being scaled 150% on the secondary monitor. If Windows thinks the application is just high DPI system aware, not per monitor, then it does the bitmap scaling to make it appear at 100%.
From what I've read, when per monitor awareness is enabled, the application must respond to a resize notification that Windows sends to tell it that it is now on another monitor with a different scaling factor. Then it is up to the application to "rescale" itself (however that is done). Windows doesn't do the bitmap scaling in that situation. But if the application isn't handling that message, it just retains the 150% scaling (system wide scaling factor) no matter what monitor it is on.